How Do You Spell ANAPLEROTIC?
Pronunciation: [ˌanɐpləɹˈɒtɪk] (IPA) 
Correct spelling for the English word "Anaplerotic" is [ˌanɐpləɹˈɒtɪk], [ˌanɐpləɹˈɒtɪk], [ˌa_n_ɐ_p_l_ə_ɹ_ˈɒ_t_ɪ_k] (IPA phonetic alphabet).
Pronunciation: [ˌanɐpləɹˈɒtɪk] (IPA)
Correct spelling for the English word "Anaplerotic" is [ˌanɐpləɹˈɒtɪk], [ˌanɐpləɹˈɒtɪk], [ˌa_n_ɐ_p_l_ə_ɹ_ˈɒ_t_ɪ_k] (IPA phonetic alphabet).
Anaplerotic refers to a biochemical process or substance that replenishes a particular metabolic pathway or compound within a living organism. Derived from the Greek words "ana" meaning "up" and "pleroun" meaning "to fill," anaplerotic plays a crucial role in maintaining cellular function and energy metabolism.
In the context of biochemistry, anaplerotic reactions primarily occur within the intermediary metabolism, which involves the breakdown and synthesis of various biomolecules. These reactions are responsible for the replenishment of specific intermediates that get depleted during normal metabolic processes.
Anaplerotic reactions ensure the adequate supply of these intermediates, enabling the smooth functioning of essential metabolic pathways such as the tricarboxylic acid (TCA) cycle or the citric acid cycle. These intermediates act as substrates for various enzymatic reactions, facilitating the production of ATP (adenosine triphosphate), the primary energy currency of cells.
Furthermore, anaplerosis also plays a crucial role in maintaining cellular homeostasis and preventing the accumulation of toxic metabolites. By replenishing depleted intermediates, anaplerotic reactions enable cells to efficiently utilize the available nutrients and maintain a balanced metabolic state.
The understanding and manipulation of anaplerotic processes have significant implications in various fields, including metabolism research, drug development, and medical treatments. Scientists and researchers study anaplerotic reactions to gain insights into metabolic disorders, such as diabetes or cancer, and explore potential therapeutic interventions to address these conditions.
Overall, anaplerotic serves as a fundamental mechanism for maintaining the intricate balance of metabolism within living organisms, ensuring the availability of essential intermediates and the efficient utilization of nutrients.
Relating to anaplerosis; filling a defect.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
The word "anaplerotic" is derived from the Greek prefix "ana-" meaning "up" or "back", and the Greek word "pleroun" meaning "to fill" or "to complete". In Greek, "anapleroun" refers to replenishing or restoring something to its full capacity. This Greek term was later borrowed into English, and the suffix "-ic" was added to form the adjective "anaplerotic", which refers to substances or processes that have the ability to replenish or restore something.
