AIDS-related lymphoma refers to a type of cancer that affects the lymphatic system and occurs in individuals who are infected with the human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS). It is a form of non-Hodgkin lymphoma that develops due to a weakened immune system associated with advanced HIV infection.
The lymphatic system is responsible for maintaining the body's immune response by producing and circulating lymphocytes (a type of white blood cell) and clearing waste materials. In AIDS-related lymphoma, these lymphocytes become malignant or cancerous due to the impaired immune function associated with HIV/AIDS.
AIDS-related lymphoma typically occurs in individuals with low CD4 cell counts, indicating severe immunodeficiency. There are two main types of AIDS-related lymphoma: primary central nervous system lymphoma (PCNSL) and systemic non-Hodgkin lymphoma. PCNSL affects the brain and spinal cord, while systemic non-Hodgkin lymphoma involves lymph nodes and other organs throughout the body.
Symptoms of AIDS-related lymphoma may include enlarged lymph nodes, persistent fever, night sweats, weight loss, fatigue, and neurological symptoms (in PCNSL). Diagnosis often involves a biopsy of affected tissue and further examination under a microscope.
Treatment for AIDS-related lymphoma typically involves a combination of chemotherapy, radiation therapy, and antiretroviral therapy (ART) to control HIV infection and improve immune function. Prognosis varies depending on the type and stage of lymphoma, overall health status, and response to treatment. Regular medical monitoring and adherence to ART are essential for managing AIDS-related lymphoma and preventing its recurrence.