ZUCKER RATS Meaning and
Definition
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Zucker rats, specifically known as Zucker Fatty Rats (ZFR), are a widely utilized strain of laboratory rats that have been selectively bred to develop obesity and metabolic abnormalities. The ZFR strain was established by cross-breeding an obese female rat with a lean male rat, and subsequent generations were selectively bred based on their propensity for weight gain and metabolic dysregulation.
These rats exhibit a genetic mutation that affects their regulation of appetite and energy metabolism, specifically in relation to glucose and lipid metabolism. As a result, Zucker rats typically develop severe obesity, hyperphagia (excessive food intake), insulin resistance, hyperinsulinemia (increased insulin levels), and impaired glucose tolerance. They also often exhibit higher levels of circulating triglycerides and cholesterol.
Due to their metabolic profile, Zucker rats have become a valuable animal model in the study of obesity, type 2 diabetes, and related metabolic disorders. Researchers commonly use Zucker rats to investigate the underlying mechanisms of these conditions, explore potential therapeutic interventions, and evaluate the efficacy of novel treatments. The rats' genetic predisposition to obesity and metabolic abnormalities allows scientists to study the effects of different diets, medications, and lifestyle interventions on the development and progression of these disorders.
The Zucker rat strain has contributed significantly to our understanding of the complex metabolic processes involved in obesity and related conditions, aiding in the development of interventions and therapies aimed at addressing these health issues in humans.
Common Misspellings for ZUCKER RATS
- xucker rats
- sucker rats
- aucker rats
- zycker rats
- zhcker rats
- zjcker rats
- zicker rats
- z8cker rats
- z7cker rats
- zuxker rats
- zuvker rats
- zufker rats
- zudker rats
- zucjer rats
- zucmer rats
- zucler rats
- zucoer rats
- zucier rats
- zuckwr rats
- zucksr rats
Etymology of ZUCKER RATS
The term "Zucker rats" is derived from the German word "Zucker" meaning "sugar" and "rats", which refers to the specific laboratory rat strain used in research known as the "Wistar Institute Zucker Fatty (WF) rat". The WF rat strain was developed at the Wistar Institute in Philadelphia, USA, by Dr. Walter F. Ward in the 1960s for the study of diabetes and obesity. These rats possess a genetic mutation that causes them to develop obesity and type 2 diabetes, making them a valuable model for research into these conditions. The name "Zucker rats" signifies that they are rats used in experiments related to sugar metabolism, obesity, and diabetes.
Similar spelling words for ZUCKER RATS
- scary rats,
- scary rides,
- square roots.
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