How Do You Spell X LINKED RECESSIVE HEREDITARY SPASTIC PARAPLEGIA?

Pronunciation: [ˈɛks lˈɪŋkt ɹɪsˈɛsɪv hɪɹˈɛdɪtəɹi spˈastɪk pˌaɹəplˈiːd͡ʒə] (IPA)

X linked Recessive Hereditary Spastic Paraplegia is a rare genetic disorder that affects the function of the spinal cord. The spelling of the word can be explained using IPA phonetic transcription, with the "X" referring to the X chromosome and the "h" in "hereditary" being a silent letter. The word "spastic" is pronounced with a long "a" sound, while "paraplegia" ends with the "ia" diphthong. This condition is inherited in a recessive manner, meaning that an individual must inherit two copies of the affected gene to develop the disorder.

X LINKED RECESSIVE HEREDITARY SPASTIC PARAPLEGIA Meaning and Definition

1. X-linked recessive hereditary spastic paraplegia (HSP) is a neurological disorder characterized by progressive spasticity and weakness in the lower limbs. This condition is caused by mutations in genes located on the X chromosome, leading to a deficiency or malfunction of specific proteins necessary for normal function of the nervous system.

   The term "recessive" indicates that the disorder is only expressed when an individual inherits two copies of the mutated gene, one from each parent. Since the gene responsible for X-linked recessive HSP is located on the X chromosome, the disorder primarily affects males. However, females who carry one copy of the mutated gene can be carriers and may experience mild symptoms.

   "Hereditary" refers to the inherited nature of the condition, meaning it is passed down from parent to child through genetic transmission. Each child of an affected individual has a 50% chance of inheriting the mutated gene and potentially developing the disorder.

   "Spastic paraplegia" describes the main symptomatology of the condition, which is progressive stiffness and muscle weakness in the lower limbs. This results in difficulties with walking, balance, and coordination. In some cases, the upper limbs can also be affected.

   Overall, X-linked recessive hereditary spastic paraplegia is a rare genetic disorder that affects the nervous system and primarily manifests as progressive spasticity and weakness in the lower limbs. More research is needed to better understand the precise underlying mechanisms and potential treatment options for this condition.

Common Misspellings for X LINKED RECESSIVE HEREDITARY SPASTIC PARAPLEGIA

• z linked recessive hereditary spastic paraplegia
• c linked recessive hereditary spastic paraplegia
• d linked recessive hereditary spastic paraplegia
• s linked recessive hereditary spastic paraplegia
• x kinked recessive hereditary spastic paraplegia
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• x linjed recessive hereditary spastic paraplegia
• x linmed recessive hereditary spastic paraplegia
• x linled recessive hereditary spastic paraplegia