A viral vector is a genetically engineered or modified virus that is used as a delivery system for introducing genetic material into living cells. It is an important tool in genetic research and biotechnology as it allows for the efficient transfer of desired genetic material into cells, including those that are difficult to reach or manipulate using other methods.
Viral vectors are typically derived from viruses that naturally infect humans or other species. These viruses are selected for their ability to efficiently enter and deliver genetic material to target cells. The viral genetic material is then modified or removed, and replaced with the desired genetic material that needs to be delivered into the target cells.
The modified viral vector is capable of entering the target cells, typically by binding to specific receptors on the cell surface and gaining entry through internalization. Once inside the cells, the viral vector releases the genetic material it carries, allowing it to integrate into the cellular genome or to be expressed independently.
Viral vectors are widely used in gene therapy, where they are employed to deliver therapeutic genes into cells to correct genetic disorders or to produce therapeutic molecules. They are also utilized in genetic engineering and biotechnology research to study gene function, manipulate gene expression, or produce large quantities of specific proteins of interest.
The use of viral vectors has revolutionized the field of genetic research and provides a powerful tool for introducing genetic material into cells efficiently and effectively.
The etymology of the word "viral vector" can be traced back to two key terms: "viral" and "vector".
- Viral: The word "viral" is derived from the Latin word "virus", meaning "poison" or "slime". In modern usage, it refers to infectious agents or particles that can replicate within living cells, causing disease or other biological effects.
- Vector: The term "vector" comes from the Latin word "vectōr", which means "carrier". In the field of biology and genetics, a vector is an agent that carries and transfers genetic material or information from one organism to another. It acts as a vehicle for delivering specific genes or DNA sequences into target cells or organisms.
Combining these two terms, "viral vector" refers to a carrier system that utilizes viruses to deliver genetic material, such as therapeutic genes or DNA sequences, into target cells.