Viral cell transformation is a process in which a virus induces permanent changes in the genetic material or cellular characteristics of an infected cell, leading to an altered behavior, growth pattern, or function of the affected cell. This transformation is usually associated with certain types of oncogenic or cancer-causing viruses.
During viral cell transformation, the genetic material of the virus integrates into the host cell's genome, bringing about various alterations in the cellular machinery. This can result in the deregulation of normal cellular functions, uncontrolled cellular growth, and the formation of tumors.
The transformed cells commonly exhibit several distinct characteristics, including increased proliferation rate, loss of contact inhibition (the ability to stop growing upon contact with neighboring cells), altered cell shape and size, and decreased response to normal cell death signals. These changes contribute to the increased survival and proliferation of the infected cells, often leading to the formation of cancerous tumors.
Viral cell transformation plays a key role in the development of certain types of cancers, such as cervical cancer (caused by human papillomavirus) and liver cancer (caused by hepatitis B and C viruses).
Understanding the mechanisms of viral cell transformation is crucial for developing strategies to prevent and treat virus-associated cancers.