Verner Morrison Syndrome, also known as Verner-Morrison Syndrome or WDHA (Watery Diarrhea, Hypokalemia, Achlorhydria) syndrome, is a rare endocrine disorder characterized by a group of symptoms that manifest due to the overproduction of a hormone called vasoactive intestinal peptide (VIP). This condition is named after the two physicians, Bjarne I. Verner and John H. Morrison, who first described it in the medical literature.
When an individual has Verner Morrison Syndrome, their body produces excessive amounts of the hormone VIP, which primarily affects the gastrointestinal system. The syndrome is associated with chronic, watery diarrhea that can be severe and persist for prolonged periods. Patients often experience electrolyte imbalances due to excessive fluid loss, leading to low levels of potassium in the blood, resulting in a condition known as hypokalemia. Additionally, reduced levels of stomach acid, known as achlorhydria, are a common feature of this disorder.
The exact cause of Verner Morrison Syndrome is not fully understood, but it is believed to be caused by the development of tumors, known as VIPomas, in the pancreas or other neuroendocrine tissues. These tumors continuously produce excess amounts of VIP, leading to the characteristic symptoms.
Treatment for Verner Morrison Syndrome typically involves surgical removal of the VIPoma tumor whenever possible. Additional interventions may include medications to control symptoms such as diarrhea and hypokalemia. Regular monitoring of electrolyte levels and gastrointestinal function is crucial to manage this condition effectively. Early diagnosis and treatment are important to prevent complications associated with chronic diarrhea and electrolyte imbalances.
