Vasopressin Associated Neurophysin (AVP-NP) is a neuropeptide hormone synthesized in the hypothalamus and released by the posterior pituitary gland in response to certain physiological signals. It consists of two subunits - vasopressin and neurophysin, which are linked together.
Vasopressin, also known as antidiuretic hormone (ADH), plays a crucial role in regulating water balance in the body. It acts on the kidneys, stimulating the reabsorption of water and reducing the urine output. Additionally, vasopressin acts as a vasoconstrictor, narrowing the blood vessels, thereby increasing blood pressure.
The other component, neurophysin, serves as a carrier molecule for vasopressin, facilitating its transport from the hypothalamus to the posterior pituitary gland for release into the bloodstream.
Together, vasopressin and neurophysin form a complex that is responsible for the production, release, and transport of vasopressin throughout the body. Deficiencies or abnormalities in vasopressin-associated neurophysin can lead to disorders such as diabetes insipidus, characterized by excessive thirst and urination.
AVP-NP is a crucial component of the neuroendocrine system, regulating water balance and maintaining blood pressure. Studying its function and abnormalities has important implications for understanding and treating various physiological and pathological conditions related to water balance and blood pressure regulation.
