How Do You Spell UROPORPHYRINOGEN III SYNTHETASE?

Pronunciation: [jˈʊ͡əɹəpˌɔːfɪɹˌɪnəd͡ʒən ɹˌə͡ʊmən θɹˈiː sˈɪnθɪtˌe͡ɪs] (IPA)

Uroporphyrinogen III Synthetase is a lengthy and complex tongue-twister of a word commonly used in biochemistry. The first part, "Uroporphyrinogen," is pronounced /juːrəʊˌpɔːfɪˈrɪnədʒən/. This is followed by "III Synthetase," which is pronounced /θraɪ/, and finally, "Synthetase," which is pronounced /ˈsɪnθəteɪs/. This word is usually spelled in its entirety, including the Roman numeral "III." This spelling helps to distinguish this particular enzyme from others in the same biosynthetic pathway.

UROPORPHYRINOGEN III SYNTHETASE Meaning and Definition

1. Uroporphyrinogen III synthetase, also known as UROS, is an enzyme that plays a vital role in the heme biosynthesis pathway. The heme biosynthesis pathway is responsible for the production of heme, a crucial molecule found in numerous proteins and enzymes involved in various physiological processes.

   Uroporphyrinogen III synthetase specifically catalyzes the stepwise conversion of hydroxymethylbilane to uroporphyrinogen III, a key precursor in the heme biosynthesis pathway. This enzyme is involved in the fifth step of the pathway and operates by condensing four molecules of hydroxymethylbilane, while simultaneously releasing two molecules of water.

   The activity of uroporphyrinogen III synthetase is regulated by several factors, including the availability of substrate molecules and environmental conditions. Any disruption or mutation in the uroporphyrinogen III synthetase gene can lead to a deficiency or malfunction of this enzyme, resulting in a condition known as congenital erythropoietic porphyria (CEP). CEP is a rare genetic disorder characterized by an accumulation of porphyrin precursors, leading to the production of abnormal heme molecules and subsequent symptoms such as skin photosensitivity, red urine, and various systemic complications.

   Understanding the function and regulation of uroporphyrinogen III synthetase is crucial for diagnosing and managing porphyrias, as well as studying the heme biosynthesis pathway and its implications in human health and disease.

Common Misspellings for UROPORPHYRINOGEN III SYNTHETASE

• yroporphyrinogen iii synthetase
• hroporphyrinogen iii synthetase
• jroporphyrinogen iii synthetase
• iroporphyrinogen iii synthetase
• 8roporphyrinogen iii synthetase
• 7roporphyrinogen iii synthetase
• ueoporphyrinogen iii synthetase
• udoporphyrinogen iii synthetase
• ufoporphyrinogen iii synthetase
• utoporphyrinogen iii synthetase
• u5oporphyrinogen iii synthetase
• u4oporphyrinogen iii synthetase
• uriporphyrinogen iii synthetase
• urkporphyrinogen iii synthetase
• urlporphyrinogen iii synthetase
• urpporphyrinogen iii synthetase
• ur0porphyrinogen iii synthetase
• ur9porphyrinogen iii synthetase
• urooorphyrinogen iii synthetase
• urolorphyrinogen iii synthetase