TRKA Meaning and
Definition
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TRKA is an acronym referring to the tropomyosin receptor kinase A, which is a high-affinity receptor for nerve growth factor (NGF). It is a member of the receptor tyrosine kinase (RTK) family and is predominantly found in the neural tissue. TRKA plays a crucial role in the development and survival of sympathetic and sensory neurons in the peripheral nervous system.
As a receptor, TRKA is composed of three main parts: an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain is responsible for binding to NGF, while the intracellular domain possesses kinase activity, meaning it can initiate a cascade of biochemical reactions upon ligand binding. This intracellular signaling pathway is crucial for regulating cell growth, differentiation, and survival.
The activation of TRKA occurs when NGF binds to its extracellular domain, triggering a conformational change in the receptor and leading to the autophosphorylation of tyrosine residues within the intracellular domain. This activated receptor can then recruit and phosphorylate various downstream signaling molecules, leading to the activation of several intracellular pathways, such as the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI3K) pathway.
Dysregulation of TRKA signaling has been associated with numerous neurological disorders, including Alzheimer's disease and various forms of cancer. Consequently, TRKA has become an important therapeutic target in the development of new drugs and therapies aimed at modulating its activity.
Common Misspellings for TRKA
- 6rka
- rtrka
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- tfrka
- ytrka
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- t6rka
- 5trka
- t5rka
- tdrka
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- trtka
- tr5ka
- t4rka
- tr4ka
- trkja
- trmka
- trkaz
- trkwa
- trkaw
- trkqa
- trkaq
- trkaa
- t rka
- tr ka
- trk a
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