TRIMETREXATE Meaning and
Definition
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Trimetrexate is a medication that is primarily used as an antimicrobial agent in the treatment of certain types of pneumonia caused by the microorganism Pneumocystis jirovecii, which commonly affects immunocompromised individuals such as those with HIV/AIDS. It belongs to a class of drugs known as antifolate agents and works by inhibiting the enzyme dihydrofolate reductase, which is necessary for the synthesis of DNA and RNA. By blocking this enzyme, trimetrexate disrupts the ability of Pneumocystis jirovecii to replicate and grow, thus helping to control the infection.
Trimetrexate is typically administered intravenously under the supervision of a healthcare professional. It is often used in combination with another medication called leucovorin, which helps to mitigate the side effects of trimetrexate by providing a source of folate that is not affected by the drug's action.
However, it is important to note that trimetrexate has certain side effects and risks associated with its use. These can include bone marrow suppression, gastrointestinal disturbances, liver toxicity, allergic reactions, and changes in blood electrolyte levels. Close monitoring and regular blood tests are typically required throughout the treatment period to ensure the drug's effectiveness and to identify and manage any potential adverse reactions.
In conclusion, trimetrexate is an antimicrobial agent used to treat pneumonia caused by Pneumocystis jirovecii. It functions by inhibiting the enzyme dihydrofolate reductase, thus preventing the microorganism from replicating and spreading. While effective, its use necessitates careful monitoring due to potential side effects.
Common Misspellings for TRIMETREXATE
- rrimetrexate
- frimetrexate
- grimetrexate
- yrimetrexate
- 6rimetrexate
- 5rimetrexate
- teimetrexate
- tdimetrexate
- tfimetrexate
- ttimetrexate
- t5imetrexate
- t4imetrexate
- trumetrexate
- trjmetrexate
- trkmetrexate
- trometrexate
- tr9metrexate
- tr8metrexate
- trinetrexate
- triketrexate
Etymology of TRIMETREXATE
The word "Trimetrexate" is derived from a combination of three components: "tri-", "methyl", and "trexate".
1. "Tri-" is a prefix that means "three" and is commonly used in chemistry and biology to indicate the presence of three identical or related parts.
2. "Methyl" refers to a chemical group composed of one carbon atom bonded to three hydrogen atoms (CH3). This functional group is commonly found in organic compounds and can be involved in various biochemical reactions.
3. "Trexate" is a suffix derived from "methotrexate", a widely used anticancer and immunosuppressant drug. "Methotrexate" is a combination of "metho-" (used to indicate the presence of a methyl group) and "trexate" (originating from "pteroylglutamic acid", the compound's chemical name).
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