TRIMETHAPHAN Meaning and
Definition
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Trimethaphan is a pharmaceutical compound that belongs to the class of drugs known as ganglionic blockers or ganglionic blocking agents. It is a synthetic quaternary ammonium compound that acts as a competitive antagonist of the nicotinic acetylcholine receptors found in the ganglia of both the sympathetic and parasympathetic divisions of the autonomic nervous system.
As a ganglionic blocker, trimethaphan works by inhibiting the transmission of nerve impulses between pre- and postganglionic neurons, leading to a reduction in the effects of both the sympathetic and parasympathetic nervous systems. This blockade results in a decrease in blood pressure and heart rate, as well as reduced secretion of various glands and involuntary muscle activity.
Trimethaphan is primarily used in medical settings as an intravenous medication for the temporary management of severe hypertension, such as during surgical procedures or in emergency situations. It helps to promote controlled hypotension (lowering of blood pressure) and smooth muscle relaxation, which can be beneficial during surgeries where controlled bleeding is required.
While trimethaphan can effectively lower blood pressure and provide other desired effects, it is important to note that it can also cause side effects such as headache, dizziness, flushing, blurred vision, dry mouth, and urinary retention. These effects are transient and generally resolve after discontinuing the drug.
Due to its mechanism of action and specific indications, trimethaphan should be administered under medical supervision by trained healthcare professionals.
Common Misspellings for TRIMETHAPHAN
- rrimethaphan
- frimethaphan
- grimethaphan
- yrimethaphan
- 6rimethaphan
- 5rimethaphan
- teimethaphan
- tdimethaphan
- tfimethaphan
- ttimethaphan
- t5imethaphan
- t4imethaphan
- trumethaphan
- trjmethaphan
- trkmethaphan
- tromethaphan
- tr9methaphan
- tr8methaphan
- trinethaphan
- trikethaphan
Etymology of TRIMETHAPHAN
The word "Trimethaphan" is a pharmaceutically derived term and its etymology can be broken down as follows:
1. Trimetha-: This part of the word is derived from the chemical compound "tri-" (meaning three) and "meth" (which refers to methyl, a functional group of three hydrogen atoms bonded to a single carbon atom), indicating the presence of three methyl (CH3) groups in the chemical structure of Trimethaphan.
2. -phan: The ending "-phan" is derived from the chemical class of drugs known as "ganglionic blocking agents" or "ganglionic blockers". These medications act on the autonomic ganglia, which are clusters of nerve cells involved in the transmission of messages between the central nervous system and peripheral nervous system. The "-phan" suffix is commonly used to describe this class of drugs.
