TRIFLUOROTHYMIDINE Meaning and
Definition
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Trifluorothymidine, also known as TFT or trifluridine, is a synthetic nucleoside analog that is used as an antiviral and antineoplastic agent. It belongs to the class of chemotherapy drugs known as pyrimidine analogs, which inhibit the synthesis of DNA and RNA by interfering with the incorporation of nucleotides into the growing DNA chain.
Trifluorothymidine is considered a prodrug, meaning that it is converted to its active form within the body. Once inside the cells, it undergoes a series of chemical reactions to ultimately form its active metabolite, trifluorodeoxyuridine triphosphate (TFdUMP). TFdUMP acts as an inhibitor of thymidylate synthase, an enzyme essential for the production of thymidine, a basic component of DNA.
By inhibiting thymidylate synthase, trifluorothymidine disrupts DNA synthesis and prevents the replication of viral and cancer cells. It is primarily used in the treatment of certain types of viral eye infections, particularly those caused by the herpes simplex virus. Trifluorothymidine eye drops are administered topically to the affected eye(s) and work by directly inhibiting viral replication.
In addition to its antiviral activity, trifluorothymidine also exhibits antineoplastic properties and is used in the treatment of certain types of cancer, such as colorectal cancer and gastric cancer. It is often used in combination with other chemotherapy drugs to enhance its efficacy.
Due to its mode of action, trifluorothymidine can cause various side effects, including eye irritation, blurred vision, and allergic reactions. It should only be used under the supervision of a healthcare professional.
Common Misspellings for TRIFLUOROTHYMIDINE
- rrifluorothymidine
- frifluorothymidine
- grifluorothymidine
- yrifluorothymidine
- 6rifluorothymidine
- 5rifluorothymidine
- teifluorothymidine
- tdifluorothymidine
- tfifluorothymidine
- ttifluorothymidine
- t5ifluorothymidine
- t4ifluorothymidine
- trufluorothymidine
- trjfluorothymidine
- trkfluorothymidine
- trofluorothymidine
- tr9fluorothymidine
- tr8fluorothymidine
- tridluorothymidine
- tricluorothymidine
Etymology of TRIFLUOROTHYMIDINE
The word "trifluorothymidine" is a compound word derived from several components.
1. "Tri-" is a prefix indicating three.
2. "Fluoro-" is a prefix indicating the presence of fluorine in a compound.
3. "Thymidine" is a nucleoside, which is composed of the nucleobase called thymine and a sugar called deoxyribose.
In summary, "trifluorothymidine" describes a compound that consists of three fluorine atoms attached to a thymidine molecule.
