TRANSTHYRETIN Meaning and
Definition
-
Transthyretin is a protein that is mainly produced by the liver and circulates in the blood. It serves as a transporter for thyroid hormones and retinol-binding protein, aiding in their distribution throughout the body. Transthyretin, also known as prealbumin, is a tetrameric protein consisting of four identical subunits, and it plays a crucial role in maintaining the stability and homeostasis of these essential molecules.
In addition to its transport function, transthyretin has been found to have other physiological roles. Research has shown its involvement in the regulation of tissue growth, neuronal development, and cell proliferation. It has also been associated with amyloidosis, a group of disorders characterized by the accumulation of abnormal protein aggregates that can cause damage to various organs, including the heart and nervous system.
Transthyretin-associated amyloidosis occurs when mutations in the transthyretin gene lead to misfolding and aggregation of the protein, forming amyloid deposits in tissues. This can result in the development of diseases such as familial amyloidotic polyneuropathy (FAP) and senile systemic amyloidosis (SSA). Symptoms of transthyretin amyloidosis can vary, depending on the affected organs, and may include peripheral neuropathy, cardiac dysfunction, and gastrointestinal problems.
Understanding the structure and function of transthyretin is important for elucidating its role in health and disease. Ongoing research aims to develop therapeutic strategies that target transthyretin amyloidosis, ultimately providing better treatment options for affected individuals.
Common Misspellings for TRANSTHYRETIN
- rransthyretin
- fransthyretin
- gransthyretin
- yransthyretin
- 6ransthyretin
- 5ransthyretin
- teansthyretin
- tdansthyretin
- tfansthyretin
- ttansthyretin
- t5ansthyretin
- t4ansthyretin
- trznsthyretin
- trsnsthyretin
- trwnsthyretin
- trqnsthyretin
- trabsthyretin
- tramsthyretin
- trajsthyretin
- trahsthyretin
Etymology of TRANSTHYRETIN
The word "Transthyretin" is derived from the combination of two terms: "trans" and "thyretin".
1. "Trans": In this context, "trans" refers to the transport function of the protein. It indicates that transthyretin is involved in the transportation of other molecules or substances.
2. "Thyretin": "Thyretin" is a term derived from "thyroxine" and "retinol-binding protein". It indicates that the protein transthyretin has an affinity for both thyroxine (a hormone produced by the thyroid gland) and retinol (a form of vitamin A).
Therefore, the word "Transthyretin" suggests a protein involved in the transport of thyroxine and retinol in the body.
