How Do You Spell TRANSPEPTIDASES?

Pronunciation: [tɹanspˈɛptɪdˌe͡ɪsɪz] (IPA)

Transpeptidases (/trænsˈpɛptɪdeɪzɪz/) is a challenging word to spell due to its complex structure and unfamiliar pronunciation. It refers to a group of enzymes involved in the synthesis of peptidoglycan, a major component of bacterial cell walls. The word is derived from "trans-", meaning across or beyond, and "peptide", which refers to the amino acid building blocks of proteins. The suffix "-ases" denotes enzymes. The IPA phonetic transcription reveals the intricate blend of sounds in this word, which can be tricky to pronounce and spell correctly.

TRANSPEPTIDASES Meaning and Definition

1. Transpeptidases are enzymes that play a crucial role in cell wall synthesis in bacteria and archaea. Specifically, they are responsible for forming cross-links between adjacent peptidoglycan chains, which provide strength and stability to the cell wall. Peptidoglycan is a complex polymer made up of long chains of alternating sugars and amino acids that make up the structural component of the cell wall in these organisms.

   Transpeptidases, also known as penicillin-binding proteins (PBPs), are located in the cell membrane and participate in the final steps of peptidoglycan synthesis. These enzymes catalyze the formation of peptide bonds between amino acids known as D-alanine residues, which are present in the peptidoglycan chains.

   The activity of transpeptidases is inhibited by certain antibiotics, such as penicillins, cephalosporins, and carbapenems. These drugs function by binding to the active site of the enzyme, blocking its ability to form cross-links between peptidoglycan chains. As a result, the bacterium's cell wall becomes weakened and more susceptible to osmotic lysis, ultimately leading to the death of the bacterial cell.

   Understanding the structure and function of transpeptidases is of great importance in the development of new antibiotics and antimicrobial therapies. By targeting these enzymes and inhibiting their activity, it is possible to disrupt the integrity of the bacterial cell wall, providing an effective means of treating bacterial infections.

Common Misspellings for TRANSPEPTIDASES

• rranspeptidases
• franspeptidases
• granspeptidases
• yranspeptidases
• 6ranspeptidases
• 5ranspeptidases
• teanspeptidases
• tdanspeptidases
• tfanspeptidases
• ttanspeptidases
• t5anspeptidases
• t4anspeptidases
• trznspeptidases
• trsnspeptidases
• trwnspeptidases
• trqnspeptidases
• trabspeptidases
• tramspeptidases
• trajspeptidases
• trahspeptidases

Etymology of TRANSPEPTIDASES

The word "transpeptidases" is derived from two components: "trans-" and "peptidases".

1. "Trans-": This prefix is derived from the Latin prefix "trans", meaning "across" or "beyond". In biology and chemistry, the prefix "trans-" is often used to describe processes, structures, or molecules that occur or act across or on opposite sides.

2. "Peptidases": This word is derived from the noun "peptide" and the suffix "-ase". A peptide is a compound consisting of two or more amino acids linked together by peptide bonds. "-ase" is a suffix used to indicate that the word refers to an enzyme or an enzyme class. In this case, "peptidases" refers to enzymes that catalyze the cleavage or breakdown of peptide bonds in proteins or peptides.