How Do You Spell TRANSCRIPTION FACTOR NF KB?

Pronunciation: [tɹanskɹˈɪpʃən fˈaktəɹ ˌɛnˈɛf kˈe͡ɪ bˈiː] (IPA)

The transcription factor NF kB is spelled using the International Phonetic Alphabet (IPA) as /trænsˈkrɪpʃən ˈfæktər ɛn ɛf keɪ biː/. The word "transcription" is spelled as /trænsˈkrɪpʃən/ and the word "factor" is spelled as /ˈfæktər/. The letters "NF" are pronounced as /ɛn ɛf/ and "kB" as /keɪ biː/. This transcription factor plays an important role in regulating gene expression and is involved in many cellular processes including inflammation and cancer.

TRANSCRIPTION FACTOR NF KB Meaning and Definition

  1. Transcription Factor NF-kB, also known as Nuclear Factor kappa B, is a protein complex that plays a crucial role in regulating genes involved in immune response, inflammation, cell survival, and proliferation. It is a transcription factor composed of subunits p50 and p65, among others, encoded by the genes NFKB1 and NFKB2, respectively.

    NF-kB operates as a transcription factor by binding to specific DNA sequences called κB sites, found in the promoter region of target genes. Upon activation, NF-kB is released from its inhibitory complex and translocates into the cell nucleus, where it binds to the κB sites and initiates the transcription of downstream genes. The activation of NF-kB can be triggered by various stimuli, such as pro-inflammatory cytokines (e.g., tumor necrosis factor-alpha), pathogen-associated molecular patterns (PAMPs), and stress signals.

    The activation of NF-kB is tightly regulated to prevent excessive or prolonged inflammatory responses. In its inactive state, NF-kB is retained in the cytoplasm through its association with inhibitory proteins known as IkBs. Various signaling pathways, such as the canonical and non-canonical pathways, regulate the degradation of IkBs, leading to the subsequent activation and nuclear translocation of NF-kB.

    Dysregulation of NF-kB has been implicated in numerous diseases, including chronic inflammation, autoimmune diseases, and cancer. Therapeutic strategies targeting NF-kB signaling are under investigation in the development of drugs to combat these diseases.

Common Misspellings for TRANSCRIPTION FACTOR NF KB

  • rranscription factor nf kb
  • franscription factor nf kb
  • granscription factor nf kb
  • yranscription factor nf kb
  • 6ranscription factor nf kb
  • 5ranscription factor nf kb
  • teanscription factor nf kb
  • tdanscription factor nf kb
  • tfanscription factor nf kb
  • ttanscription factor nf kb
  • t5anscription factor nf kb
  • t4anscription factor nf kb
  • trznscription factor nf kb
  • trsnscription factor nf kb
  • trwnscription factor nf kb
  • trqnscription factor nf kb
  • trabscription factor nf kb
  • tramscription factor nf kb
  • trajscription factor nf kb
  • trahscription factor nf kb

Infographic

Add the infographic to your website: