TRANSALDOLASE Meaning and
Definition
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Transaldolase is an enzyme that plays a vital role in the pentose phosphate pathway, which is a metabolic pathway essential for the production of NADPH and ribose-5-phosphate. It specifically catalyzes the transfer of a three-carbon dihydroxyacetone moiety from the sugar sedoheptulose-7-phosphate to the sugar with five carbon atoms, glyceraldehyde-3-phosphate. This leads to the formation of fructose-6-phosphate and erythrose-4-phosphate, allowing for the rearrangement and interconversion of various sugar molecules.
Transaldolase is a key enzyme in the non-oxidative phase of the pentose phosphate pathway, linking the sugar intermediates and facilitating the production of ribose-5-phosphate, a precursor for nucleotide synthesis. It also plays a role in the regeneration of glucose-6-phosphate, an important molecule for glucose metabolism.
In addition to its role in sugar metabolism, transaldolase has been found to exhibit other functions in different pathways. It has been associated with the regulation of apoptosis, the process of programmed cell death, and has been shown to interact with various proteins involved in cellular processes such as cell division and differentiation.
Defects or deficiencies in transaldolase activity have been linked to certain disorders, including transaldolase deficiency, a rare inherited metabolic disorder that affects the ability to metabolize certain sugars. This condition can cause severe developmental delays, liver problems, and other complications.
Common Misspellings for TRANSALDOLASE
- rransaldolase
- fransaldolase
- gransaldolase
- yransaldolase
- 6ransaldolase
- 5ransaldolase
- teansaldolase
- tdansaldolase
- tfansaldolase
- ttansaldolase
- t5ansaldolase
- t4ansaldolase
- trznsaldolase
- trsnsaldolase
- trwnsaldolase
- trqnsaldolase
- trabsaldolase
- tramsaldolase
- trajsaldolase
- trahsaldolase
Etymology of TRANSALDOLASE
The word "transaldolase" is derived from the combination of two components: "trans" and "aldolase".
1. "Trans" is a prefix that comes from the Latin word "trans", meaning "across" or "on the other side".
2. "Aldolase" is a term that describes a group of enzymes that catalyze the breakdown and formation of certain carbon-carbon bonds in organic molecules. The word "aldolase" comes from the combination of "aldo-" which refers to "aldose" (a type of sugar) and "-ase", a common suffix used in biochemistry to denote an enzyme.
Therefore, "transaldolase" refers to an enzyme that catalyzes the transfer of a group from one aldose sugar to another across a molecule.
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