TPHA Meaning and
Definition
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TPHA stands for Treponema pallidum hemagglutination assay. It is a laboratory test used for the diagnosis of syphilis, a sexually transmitted infection caused by the bacteria Treponema pallidum. TPHA is considered a non-treponemal test, which means it detects antibodies produced by the body in response to a syphilis infection, rather than directly identifying the bacteria.
During the TPHA test, a patient's blood serum is mixed with particulate antigen derived from T. pallidum. If the patient has been infected with syphilis, antibodies present in their blood sample will react with the antigen, causing agglutination or clumping. The degree of agglutination observed is used to determine the presence and stage of syphilis infection.
TPHA is considered highly specific but may have some false-positive results. Therefore, it is often used as a confirmatory test following a positive result from a screening test like the rapid plasma reagin (RPR) test. A positive TPHA result indicates the presence of syphilis antibodies and suggests a current or past infection. However, it does not determine the stage of the infection or the presence of active disease.
The TPHA test is commonly used in medical laboratories and clinics worldwide as a valuable tool in the diagnosis of syphilis. It is an important component of comprehensive screening protocols and is frequently combined with other tests to achieve accurate detection and diagnosis of this sexually transmitted infection.
Common Misspellings for TPHA
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