TNKS Meaning and
Definition
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TNKS stands for TRF1-interacting ankyrin-related ADP-ribose polymerase Tankyrase. It is an enzyme that is encoded by the TNKS gene in humans. TNKS is a member of the poly(ADP-ribose) polymerase (PARP) superfamily and is involved in various cellular processes such as telomere maintenance, mitosis, and wnt signaling.
TNKS functions as a poly-ADP ribosyltransferase enzyme that modifies target proteins by adding ADP-ribose polymers to them. Through this modification, TNKS plays a crucial role in regulating protein-protein interactions and protein stability, thereby influencing essential cellular processes. One of the well-studied targets of TNKS is the TRF1 protein, a component of the telomeric shelterin complex that protects and regulates telomeres. By interacting with TRF1, TNKS helps to control telomere length and integrity.
Furthermore, TNKS is also involved in the Wnt/β-catenin signaling pathway, which is crucial for embryonic development, tissue homeostasis, and stem cell maintenance. TNKS interacts with several components of this pathway, including Axin and β-catenin, affecting their stability and regulating Wnt signaling.
Overall, TNKS is an essential enzyme involved in critical cellular processes, ranging from telomere maintenance to cell signaling. Its role in ADP-ribosylation and protein regulation make it an intriguing target for therapeutic interventions in various diseases, including cancer and aging-related disorders.
Common Misspellings for TNKS
- ynks
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- trnks
- gtnks
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- ytnks
- tynks
- 6tnks
- t6nks
- 5tnks
- t5nks
- tnbks
- tnmks
- tjnks
- thnks
- tnlks
