THYROXINE RECEPTOR Meaning and
Definition
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Thyroxine Receptor (TR) is a protein found predominantly in the nucleus of cells that binds to and interacts with the hormone thyroxine, also known as T4. It is a member of the nuclear hormone receptor superfamily and functions as a transcription factor, meaning it regulates the expression of specific genes in response to the presence of thyroxine.
The primary role of the thyroxine receptor is to mediate the effects of thyroid hormones in various tissues and organs throughout the body. Upon binding with thyroxine, the receptor undergoes conformational changes, leading to the recruitment of coactivators or corepressors, which modulate gene transcription. This transcriptional regulation by the thyroxine receptor influences a wide range of physiological processes, including metabolism, growth, development, and differentiation.
The thyroxine receptor exists in two isoforms, alpha and beta, both of which are encoded by different genes and exhibit distinct tissue distributions. They function as homodimers, meaning they form pairs with identical subunits. The isoform-specific distribution and activity of these receptors contribute to the differential effects of thyroid hormones in various cell types.
Moreover, mutations or dysregulation of the thyroxine receptor can lead to several disorders, including resistance to thyroid hormone (RTH) syndrome, in which cells fail to respond properly to thyroid hormones. This highlights the crucial role of the thyroxine receptor in maintaining homeostasis and proper functioning of the endocrine system.
Common Misspellings for THYROXINE RECEPTOR
- rhyroxine receptor
- fhyroxine receptor
- ghyroxine receptor
- yhyroxine receptor
- 6hyroxine receptor
- 5hyroxine receptor
- tgyroxine receptor
- tbyroxine receptor
- tnyroxine receptor
- tjyroxine receptor
- tuyroxine receptor
- tyyroxine receptor
- thtroxine receptor
- thgroxine receptor
- thhroxine receptor
- thuroxine receptor
- th7roxine receptor
- th6roxine receptor
- thyeoxine receptor
- thydoxine receptor
Etymology of THYROXINE RECEPTOR
The word "thyroxine receptor" derives from two main components:
1. Thyroxine: Thyroxine, also known as T4, is a hormone produced by the thyroid gland. It plays a vital role in regulating metabolism and growth in the body.
2. Receptor: A receptor is a molecular structure or component of a cell that can bind and respond to specific substances. In the context of thyroxine, the term "receptor" refers to the specific protein or molecule that binds to thyroxine and allows it to carry out its biological effects within the body.
Therefore, "thyroxine receptor" refers to the molecular structure or protein that interacts with thyroxine hormone, facilitating its functioning and effects on various physiological processes.
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