THREONINE TRNA LIGASE Meaning and
Definition
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Threonine tRNA ligase is an enzyme responsible for the specific attachment and activation of the amino acid threonine onto its corresponding transfer RNA (tRNA) molecule during protein synthesis. It belongs to the class of ligases, which are enzymes involved in catalyzing the formation of chemical bonds.
Threonine tRNA ligase plays a crucial role in the process of translation, where the genetic information stored in the DNA is translated into functional proteins. It acts by recognizing the specific tRNA molecule that carries the threonine amino acid, and catalyzes the covalent attachment of threonine to the tRNA's acceptor stem using adenosine triphosphate (ATP) as an energy source. This step is essential for incorporating threonine into the growing polypeptide chain during protein synthesis.
The catalytic activity of threonine tRNA ligase ensures the accuracy and fidelity of protein synthesis, as it ensures that only threonine, and not other similar amino acids, is incorporated in response to the appropriate genetic codon on messenger RNA (mRNA). Mutations or dysfunctions in threonine tRNA ligase can lead to errors in protein synthesis, causing disruptions in cellular function and potential development of diseases.
Threonine tRNA ligase has been extensively studied in various organisms, including bacteria, yeast, plants, and mammals. Its detailed structure and molecular mechanisms of action have been elucidated through biochemical, biophysical, and genetic studies. The knowledge of threonine tRNA ligase has opened up opportunities to develop therapeutic interventions targeting protein synthesis for various diseases and has contributed to our understanding of the molecular basis of life.
Common Misspellings for THREONINE TRNA LIGASE
- rhreonine trna ligase
- fhreonine trna ligase
- ghreonine trna ligase
- yhreonine trna ligase
- 6hreonine trna ligase
- 5hreonine trna ligase
- tgreonine trna ligase
- tbreonine trna ligase
- tnreonine trna ligase
- tjreonine trna ligase
- tureonine trna ligase
- tyreonine trna ligase
- theeonine trna ligase
- thdeonine trna ligase
- thfeonine trna ligase
- thteonine trna ligase
- th5eonine trna ligase
- th4eonine trna ligase
- thrwonine trna ligase
- thrsonine trna ligase
