How Do You Spell THIOURIDINE?

Pronunciation: [θˌa͡ɪə͡ʊjˈuːɹɪdˌiːn] (IPA)

Thiouridine, a nucleoside found in RNA, is spelled /θaɪoʊˈjuːrɪdiːn/ in IPA phonetic transcription. The first syllable /θaɪ/ sounds like "thigh," followed by the diphthong /oʊ/ as in "go." The second syllable /juːr/ rhymes with "tour," and the third syllable /ɪdiːn/ sounds like "idiot" without the "ot." The letter "i" in the middle represents the short vowel sound /ɪ/. Thiouridine is an important component of RNA, helping to regulate the expression of genes in many organisms.

THIOURIDINE Meaning and Definition

1. Thiouridine is a naturally occurring modified nucleoside that is found in certain types of RNA molecules. It is structurally similar to the nucleoside uridine, but with the substitution of a sulfur atom for the oxygen atom at the 2' carbon position of the ribose sugar. In RNA, thiouridine is often present at specific locations, where it serves various important functions.

   One of the key roles of thiouridine is in the protection of RNA molecules against damage caused by ultraviolet (UV) radiation. The sulfur atom in thiouridine is capable of absorbing UV light, acting as a sacrificial component. It can neutralize harmful UV radiation by absorbing the energy and preventing it from causing damage to the RNA molecule.

   Thiouridine also plays a crucial role in regulating the decoding process during protein synthesis. It can enhance the accuracy and efficiency of ribosomal translation, ensuring that the correct amino acids are incorporated into the growing polypeptide chain. This is achieved by promoting the fidelity of codon-anticodon interactions in the ribosome.

   Additionally, thiouridine has been found to be involved in the modulation of RNA structure and stability. It can affect the folding and stability of RNA secondary structures, which can influence RNA-protein interactions and other cellular processes.

   Overall, thiouridine is a specialized nucleoside that contributes to various aspects of RNA function and protection. Its unique chemical properties make it an essential component in maintaining the integrity and functionality of RNA molecules.

Common Misspellings for THIOURIDINE

• thiouridin

Etymology of THIOURIDINE

The word "Thiouridine" is formed by combining two components: "Thio-" and "uridine".

"Thio-" is a prefix derived from the Greek word "theion", meaning "sulfur". It is commonly used as a prefix in chemistry to indicate the presence of a sulfur atom in a compound.

"Uridine", on the other hand, is a nucleoside, which is composed of the pyrimidine base "uracil" and the sugar "ribose". Uridine is an essential component of RNA (ribonucleic acid), a molecule involved in genetic information transfer and protein synthesis.

Therefore, "Thiouridine" refers to a modified form of uridine in which a sulfur atom is present, indicating the substitution of an oxygen atom with a sulfur atom. Thiouridine is commonly found in certain types of RNA and has specific roles in biological processes.