THERMOSPRAY Meaning and
Definition
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Thermospray refers to a specialized technique used in analytical chemistry, particularly in mass spectrometry. It involves the process of ionizing and introducing a sample into a mass spectrometer for analysis.
In thermospray, the sample is dissolved in a volatile solvent and flowed through a heated capillary tube. The solvent is vaporized and combined with a heated nebulizing gas, resulting in the formation of a fine aerosol. As the aerosol travels down the capillary, it undergoes further heating, leading to the evaporation of solvent droplets and the formation of gas-phase sample molecules.
These gas-phase sample molecules are then extracted through a vacuum interface and introduced into the mass spectrometer for analysis. Within the spectrometer, the ions are usually further separated based on their mass-to-charge ratio using mass analyzers and are finally detected.
Thermospray is an important ionization technique due to its versatility and ability to handle a wide range of compounds, including high molecular weight and non-volatile substances. It is particularly useful for the analysis of large biomolecules such as peptides, proteins, and nucleic acids.
Overall, thermospray is a powerful and widely employed method in mass spectrometry, enabling the rapid and sensitive detection and characterization of various analytes in complex samples.
Common Misspellings for THERMOSPRAY
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