TERT Meaning and
Definition
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TERT is an acronym that stands for "Telomerase Reverse Transcriptase". It refers to an enzyme that plays a critical role in maintaining the length and stability of telomeres, which are repetitive DNA sequences found at the ends of chromosomes. Telomeres act as protective caps for chromosomes, preventing them from deteriorating or fusing with neighboring chromosomes.
TERT, as a catalytic subunit of the telomerase enzyme, functions by extending and replenishing telomeres. It utilizes an RNA template within its structure to synthesize and add repetitive DNA sequences to the ends of chromosomes. This activity helps to counteract the natural shortening of telomeres that occurs with each round of cell division, and allows cells to continue dividing and replicating without compromising their genomic integrity.
The dysregulation or impairment of TERT can have significant consequences on cellular lifespan and function. Reduced TERT activity has been associated with accelerated telomere shortening, cellular senescence, and increased susceptibility to age-related diseases, such as cancer, cardiovascular diseases, and neurodegenerative disorders.
TERT has garnered significant attention in scientific research due to its potential implications in aging, cancer biology, and regenerative medicine. Understanding the mechanisms through which TERT functions can aid in the development of therapeutic strategies targeting telomere maintenance or telomerase activity, potentially leading to treatments that can influence cellular aging and disease processes.
Common Misspellings for TERT
- 6ert
- t3rt
- 6tert
- t6ert
- 5tert
- t5ert
- tedrt
- t4ert
- te4rt
- t3ert
- te3rt
- tefrt
- tertt
- te5rt
- ter5t
- teryt
- ter6t
- tert6
- tert5
- ttert
- t ert
- ter t
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