The "Terminator Codon" is a sequence of three nucleotides in DNA that signals the end of a gene's transcription into messenger RNA. The spelling of this word is /ˈtɜːrmɪneɪtər ˈkəʊdɒn/, with the stress on the second syllable of "terminator" and the first syllable of "codon." The IPA phonetic transcription shows that the long vowel sound of "er" is stressed, followed by a schwa and a velar nasal in "codon," indicating the pronunciation of the word in scientific dialogue.
A terminator codon, also known as a stop codon, is a specific sequence of three nucleotides in a messenger RNA (mRNA) molecule that signals the termination of protein synthesis during translation. It is one of the three possible termination codons, including UAA (ochre), UAG (amber), and UGA (opal), found in the genetic code. The primary function of a terminator codon is to act as a molecular stop signal, causing the ribosome to cease protein production.
When a ribosome encounters a terminator codon during translation, it recognizes the code and releases the newly synthesized polypeptide chain from the ribosome. This process signifies the completion of protein synthesis and enables the subsequent folding, modification, and transport of the protein to its designated cellular location.
Terminator codons play a critical role in maintaining the correct reading frame and integrity of the genetic code, preventing premature elongation and ensuring the accurate translation of mRNA into protein. Although protein synthesis is typically terminated by these codons, certain exceptions exist where stop codons may be ignored or modified in specific organisms or cellular processes.
Understanding the function and importance of terminator codons is essential in deciphering the complexities of gene expression and protein synthesis, contributing to advancements in genetic research and biotechnology applications.
The term "Terminator Codon" is derived from the field of molecular biology and genetics.
The word "Terminator" refers to a specific DNA sequence in a gene that signals the end of protein synthesis during translation. It serves as a stop signal, ending the process of converting genetic information into a protein. The term "Terminator" is used metaphorically to describe this function of stopping or terminating the translation process.
The word "Codon" refers to a three-nucleotide sequence in a DNA or RNA molecule that codes for a specific amino acid, or serves as a start or stop signal in the protein synthesis process. In this context, "Terminator Codon" specifically refers to a codon sequence that acts as a termination signal.
Therefore, "Terminator Codon" combines these two terms to describe a specific nucleotide sequence in a gene that functions as a stop signal during protein synthesis.