TBAF Meaning and
Definition
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TBAF, an acronym for "Tetra-n-butylammonium Fluoride," is a chemical compound widely used in organic synthesis and various laboratory applications. It is a quaternary ammonium salt that consists of a tetra-n-butylammonium cation (C16H36N+) and a fluoride anion (F-). TBAF is a highly reactive and effective source of fluoride ions, making it a valuable reagent in organic chemistry reactions.
TBAF is generally available as a white solid, often in a powder or crystalline form. It is commonly utilized as a fluoride source due to its unique characteristics, including its solubility in organic solvents like acetone and tetrahydrofuran (THF). It is important to note that TBAF is superior to other fluoride sources, such as sodium fluoride or silver fluoride, which have limitations in solubility and reactivity.
This compound finds various applications in organic synthesis, primarily as a promoter or catalyst for certain reactions. TBAF is commonly employed to activate silicon-based protecting groups, remove protecting groups on carbonyl compounds, cleave ethers, silylate alcohols, and enable nucleophilic aromatic substitutions, among others. It is also used in pharmaceutical research, as well as in the synthesis of complex organic molecules for industrial and academic purposes.
In summary, TBAF is a potent and versatile reagent utilized for introducing fluoride ions into organic chemistry reactions. Its high solubility in organic solvents and ability to activate various functional groups makes it an indispensable tool for researchers and chemists in laboratory settings.
Common Misspellings for TBAF
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