How Do You Spell SUZUKI COUPLING?

Pronunciation: [suːzˈuːki kˈʌplɪŋ] (IPA)

The term "Suzuki coupling" is a widely used term in chemistry that refers to a reaction between two carbon-based molecules. The word takes its name from the Japanese chemist, Akira Suzuki, who developed the reaction method. The pronunciation of "Suzuki" is generally [sʊzʊki] in IPA phonetic transcription, with a stressed first syllable and a short "u" sound. The spelling of the word follows typical English phonetic rules, and the double "z" indicates the sound of a voiced consonant. Overall, "Suzuki coupling" is a significant term in the field of organic chemistry.

SUZUKI COUPLING Meaning and Definition

1. Suzuki coupling is a type of chemical reaction that involves the cross-coupling of two different organic compounds or molecules, using a palladium catalyst and a base. It was first developed by Akira Suzuki, a Japanese chemist, in the late 1970s.

   In this reaction, a halide compound (typically an aryl or vinyl halide) reacts with an organoboron compound (such as an arylboronic acid or an arylboronate ester) in the presence of a palladium catalyst, usually a palladium(0) complex. The reaction proceeds through a series of steps, including oxidative addition, transmetalation, and reductive elimination, resulting in the formation of a carbon-carbon bond between the two starting compounds.

   Suzuki coupling is widely used in organic synthesis and drug discovery processes, as it allows for the efficient construction of complex organic molecules. It offers several advantages, including mild reaction conditions, broad substrate scope, and high functional group tolerance. Additionally, the use of boron compounds as coupling partners provides an easy access to a wide range of aryl and heteroaryl derivatives.

   The Suzuki coupling reaction has found applications in various fields, including the synthesis of pharmaceuticals, agrochemicals, and materials science. It has significantly impacted the development of new drugs and the synthesis of complex natural products. With its versatility and synthetic utility, Suzuki coupling has become one of the most widely used methods for carbon-carbon bond formation in organic chemistry.

Etymology of SUZUKI COUPLING

The term "Suzuki coupling" is named after the Japanese chemist Akira Suzuki, who developed this particular type of chemical reaction in the 1970s. The method involves the cross-coupling of an organoboron compound with an organohalide or an aryl triflate using a palladium catalyst to form a carbon-carbon bond.

Due to the significant contributions made by Akira Suzuki, this reaction is widely known as the Suzuki coupling in the field of organic chemistry. It is worth noting that Suzuki was awarded the Nobel Prize in Chemistry in 2010, along with Richard F. Heck and Ei-ichi Negishi, for the development of palladium-catalyzed cross-coupling reactions, including the Suzuki coupling.