Subunit vaccines are a type of vaccine that only contains specific proteins or fragments of the pathogen. The word "subunit" is pronounced /ˈsʌb.juː.nɪt/ in IPA phonetic transcription, with the stress on the first syllable. The "sub-" prefix means "under" or "less than," while "unit" refers to an individual component. Therefore, "subunit" refers to a smaller part of a larger whole. In the context of vaccines, subunit vaccines are a more targeted and specific approach to inducing immunity.
Subunit vaccines are a type of vaccine that contain only specific components or subunits of the pathogen (such as proteins or polysaccharides) rather than the whole organism. They are designed to stimulate an immune response without introducing the complete pathogen into the body. The subunits selected for inclusion in the vaccine are usually those that are important for the pathogen's survival, virulence, or ability to cause disease.
These vaccines are created by isolating and purifying the desired subunit(s) from the pathogen or by using recombinant DNA technology to produce the subunit(s) in a laboratory. Once isolated, the subunit(s) are typically combined with an adjuvant – a substance that enhances the immune response – to improve the effectiveness of the vaccine.
Subunit vaccines are often preferred over whole-pathogen vaccines because they focus the immune response on the most relevant and important components of the pathogen. This can reduce the risk of adverse reactions and improve the safety profile of the vaccine. Additionally, subunit vaccines can be more easily produced, stored, and transported compared to whole-pathogen vaccines.
However, one of the challenges of using subunit vaccines is that they may not always be as immunogenic as whole-pathogen vaccines. Therefore, researchers may employ various strategies, such as incorporating adjuvants or using novel delivery systems, to enhance the immune response and improve the efficacy of subunit vaccines.
The word "subunit vaccines" consists of two parts: "subunit" and "vaccines".
The term "subunit" refers to a smaller constituent part of a larger entity. In the context of vaccines, it refers to the antigenic components of a pathogen that are responsible for triggering an immune response. These components are usually proteins or protein fragments derived from the pathogen.
The word "vaccines" originates from the Latin word "vaccinus", which means "of or relating to cows". This term was first introduced by Edward Jenner, an English physician, in the late 18th century when he observed that milkmaids who contracted cowpox from cows seemed to be protected against smallpox. Jenner used material from cowpox lesions to inoculate individuals, providing protection against smallpox.