How Do You Spell STROMELYSIN?

Pronunciation: [stɹˈə͡ʊmlɪsˌɪn] (IPA)

The word "Stromelysin" is a term used to refer to a family of proteolytic enzymes. The word is spelled as [strohm-uh-lahy-sin], with stress on the second syllable. The "t" in the first syllable is silent, and the "o" is pronounced as a schwa sound. The "y" in the second syllable is pronounced as the "i" in "bit". The word is of Greek origin, with "stroma" meaning "bed" and "lys" meaning "to break down", hence "stromelysin" refers to an enzyme that breaks down the extracellular matrix of the connective tissue bed.

STROMELYSIN Meaning and Definition

1. Stromelysin is an enzyme belonging to the matrix metalloproteinase (MMP) family, primarily involved in the degradation and remodeling of extracellular matrix components in various biological processes. It is also known as matrix metalloproteinase-3 (MMP-3).

   Stromelysin plays a crucial role in tissue homeostasis, wound healing, and tissue repair. It is produced by various cells, including fibroblasts, macrophages, and neutrophils, and is often induced in response to inflammatory signals. It is secreted as a latent proenzyme and requires activation for its enzymatic activity.

   Once activated, stromelysin exhibits proteolytic activity, targeting various extracellular matrix molecules such as collagen, elastin, proteoglycans, and fibronectin. It is involved in the degradation and remodeling of these components, thereby facilitating tissue reconstruction during physiological processes like embryonic development, angiogenesis, and tissue repair after injury.

   Stromelysin is also implicated in pathological conditions, particularly those associated with chronic inflammation, tissue destruction, and remodeling. Excessive activity of stromelysin has been linked to diseases like rheumatoid arthritis, atherosclerosis, and certain types of cancer, where it contributes to the destruction of joint tissues, progression of plaque formation in blood vessels, and tumor invasion and metastasis.

   In summary, stromelysin is an enzyme involved in the degradation and remodeling of extracellular matrix components, playing a crucial role in tissue homeostasis, wound healing, and tissue repair. It has both physiological and pathological implications, making it an important target for therapeutic interventions.

Common Misspellings for STROMELYSIN

• atromelysin
• ztromelysin
• xtromelysin
• dtromelysin
• etromelysin
• wtromelysin
• srromelysin
• sfromelysin
• sgromelysin
• syromelysin
• s6romelysin
• s5romelysin
• steomelysin
• stdomelysin
• stfomelysin
• sttomelysin
• st5omelysin
• st4omelysin
• strimelysin
• strkmelysin

Etymology of STROMELYSIN

The word "Stromelysin" is derived from its biological function and the suffix "-lysin".

"Stromelysin" refers to a group of enzymes known as matrix metalloproteinases (MMPs) that are involved in the breakdown of extracellular matrix proteins in tissues. These enzymes were first isolated from fibroblasts (connective tissue cells) present in the stroma, which is the supportive framework of bodily tissues.

The suffix "-lysin" is derived from the Greek word "lysis", meaning "loosen" or "break down". This suffix is commonly used in the naming of enzymes involved in the breakdown or degradation of specific substances.

Therefore, "Stromelysin" literally means an enzyme that causes the breakdown or lysis of components within the stroma or extracellular matrix, reflecting its biological function.