How Do You Spell SSPE?
Pronunciation: [ˈɛsspˈiː] (IPA) 
Correct spelling for the English word "sspe" is [ˈɛsspˈiː], [ˈɛsspˈiː], [ˈɛ_s_s_p_ˈiː] (IPA phonetic alphabet).
Pronunciation: [ˈɛsspˈiː] (IPA)
Correct spelling for the English word "sspe" is [ˈɛsspˈiː], [ˈɛsspˈiː], [ˈɛ_s_s_p_ˈiː] (IPA phonetic alphabet).
Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, and fatal neurological disorder that affects the central nervous system (CNS). It occurs as a delayed complication of a previous infection with the measles virus, also known as the paramyxovirus. SSPE develops primarily in individuals who had measles infection during early childhood, typically before the age of two. The disease has a long incubation period, ranging from six to eight years, after which it manifests symptoms.
The onset of SSPE is characterized by a gradual deterioration of mental and physical abilities. Patients may experience personality changes, behavioral disturbances, deterioration in cognitive functions, and decline in motor skills. As the disease progresses, neurological symptoms worsen, including muscle stiffness, myoclonic jerks, and seizures. Individuals affected by SSPE may also exhibit vision impairment, involuntary eye movements, and difficulty walking.
SSPE is caused by persistent measles virus infection in the brain due to an inability of the immune system to eliminate it completely. Over time, the virus causes inflammation, demyelination, and sclerosis in the brain, leading to the progressive degeneration of neurons.
Unfortunately, there is currently no cure for SSPE, and treatment focuses on symptomatic and supportive measures to alleviate the symptoms and improve the quality of life for affected individuals. Vaccination against measles remains the most effective preventive measure to decrease the risk of developing SSPE.
