How Do You Spell SRC HOMOLOGY DOMAIN?

Pronunciation: [ˌɛsˌɑːsˈiː həmˈɒləd͡ʒi dəmˈe͡ɪn] (IPA)

The src Homology Domain is a structural unit found in proteins involved in cellular signaling. The word "src" is spelled with the IPA phonetic transcription /sɜːrkiː/ which represents the sounds /s/ for "s", /ɜː/ for "er", /r/ for the rolled "r" and /kiː/ for the vowel sounds "ee". Therefore, the correct spelling of the word is "src" not "sarc" as commonly mistaken. Understanding the correct phonetic transcription of words is essential for accurate communication in scientific research.

SRC HOMOLOGY DOMAIN Meaning and Definition

1. The Src Homology (SH) domain is a protein-protein interaction module typically found in signaling proteins involved in various cellular processes. It is named after Src kinase, the prototypical protein tyrosine kinase that contains this domain. The SH domain is characterized by its ability to bind to phosphotyrosine residues and can mediate protein-protein interactions involved in signal transduction.

   The SH domain is about 50-70 amino acids in length and consists of a conserved fold composed of a central β-sheet surrounded by α-helices. It is classified into three subfamilies based on their sequence homology and structural features: SH2 (Src Homology 2), SH3 (Src Homology 3), and SH4.

   The SH2 domain specifically recognizes and binds to phosphorylated tyrosine residues within target proteins, serving as a recognition module for various downstream signaling events. It plays a crucial role in regulating cellular processes such as cell growth, differentiation, and immune response by interacting with other proteins involved in signal transduction pathways.

   The SH3 domain, on the other hand, facilitates protein-protein interactions by binding to proline-rich sequences found in various proteins. It acts as a molecular scaffold, assembling multi-protein complexes and regulating cellular processes like cytoskeletal organization and membrane trafficking.

   Overall, the SH domain serves as a versatile module in signaling proteins, allowing them to engage in critical protein-protein interactions and coordinate complex cellular processes.

Common Misspellings for SRC HOMOLOGY DOMAIN

• arc homology domain
• zrc homology domain
• xrc homology domain
• drc homology domain
• erc homology domain
• wrc homology domain
• sec homology domain
• sdc homology domain
• sfc homology domain
• stc homology domain
• s5c homology domain
• s4c homology domain
• srx homology domain
• srv homology domain
• srf homology domain
• srd homology domain
• src gomology domain
• src bomology domain
• src nomology domain
• src jomology domain