SPLEEN FOCUS FORMING VIRUSES Meaning and
Definition
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Spleen Focus Forming Viruses (SFFVs) are a group of retroviruses that have the ability to induce the formation of tumor-like nodules in the spleen of infected animals. These viruses primarily infect mice and have been extensively studied as model systems to understand the mechanisms of cancer development and immune responses.
SFFVs belong to the family Retroviridae and are classified under the subgroup of murine leukemia viruses (MLVs). They are characterized by their ability to transform the cells of the spleen, leading to the formation of multicellular foci or nodules. These nodules are composed of a mixture of transformed and non-transformed cells, and their formation is mediated by the viral oncogenes present in the SFFVs.
The oncogenes carried by SFFVs are integrated into the host genome during infection and are responsible for driving the transformation of infected cells. These oncogenes include v-fos and v-sis, which are derived from cellular proto-oncogenes that have been captured and modified by the viral genome.
SFFVs have been widely used in research to study the molecular basis of carcinogenesis and the interaction between viruses and the immune system. They have provided valuable insights into the oncogenic potentials of retroviruses and have contributed to the understanding of the immune responses mounted against viral infections and tumor development.
Overall, Spleen Focus Forming Viruses are a group of retroviruses that are capable of inducing the formation of tumor-like nodules in the spleen of infected animals, and their study has greatly advanced our knowledge of cancer biology and immunology.
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