SMALL T ANTIGEN Meaning and
Definition
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Small T antigen refers to a protein molecule encoded by the early region of the simian virus 40 (SV40), a virus belonging to the polyomaviridae family. The Small T antigen consists of 174 amino acids and is a non-transforming protein with various functions that play a crucial role in the viral life cycle and its oncogenic potential.
In the context of viral infection, Small T antigen is essential for viral replication and acts by interacting with host cellular factors to regulate several cellular pathways. It is involved in autophagy induction, promoting the destruction of host cell structures to create an ideal intracellular environment for viral replication. Additionally, Small T antigen modulates the cell cycle, mainly by binding and inactivating tumor suppressor proteins such as p53 and retinoblastoma protein (pRb). By inhibiting these tumor suppressors, Small T antigen promotes cell cycle progression, DNA synthesis, and ultimately viral replication.
Furthermore, Small T antigen can also interact with host signaling proteins, such as protein phosphatase 2A (PP2A), thereby manipulating key cellular signaling cascades involved in cell survival and growth. This interaction with PP2A allows Small T antigen to act as an oncoprotein, contributing to the development of SV40-associated tumors. Studies have shown that Small T antigen-mediated dysregulation of cellular pathways can lead to uncontrolled cell proliferation and evasion of host immune responses.
In summary, Small T antigen is a protein encoded by the SV40 virus that plays critical roles in viral replication, manipulation of host cellular pathways, and contributing to the development of viral-associated tumors. This protein's multifunctionality and its interactions with various cellular factors make it a significant component of SV40's pathogenic mechanisms.
Common Misspellings for SMALL T ANTIGEN
- amall t antigen
- zmall t antigen
- xmall t antigen
- dmall t antigen
- emall t antigen
- wmall t antigen
- snall t antigen
- skall t antigen
- sjall t antigen
- smzll t antigen
- smsll t antigen
- smwll t antigen
- smqll t antigen
- smakl t antigen
- smapl t antigen
- smaol t antigen
- smalk t antigen
- smalp t antigen
- smalo t antigen
- small r antigen
