Small Follicular Center Cell Lymphoma, also known as small B-cell lymphoma or small B-cell lymphoma of the follicle, is a type of non-Hodgkin lymphoma (NHL) characterized by the presence of small cells within lymph node follicles. It is considered to be a low-grade or indolent lymphoma, meaning it typically progresses slowly compared to more aggressive forms of lymphoma.
This type of lymphoma primarily affects the B-lymphocytes, a type of white blood cell involved in the immune system's response to infections. The small cells in this lymphoma resemble the normal B-cells found in the lymph follicles, but they have acquired genetic mutations that cause uncontrolled cell growth.
Patients with small follicular center cell lymphoma often present with painless enlarged lymph nodes, most commonly in the neck, armpits, or groin. Other possible symptoms include fatigue, night sweats, unexplained weight loss, and recurrent infections.
The diagnosis of small follicular center cell lymphoma typically involves a combination of clinical features, physical examination, laboratory tests, and a biopsy of an affected lymph node. The tumor cells are examined under a microscope to determine their characteristic appearance and grade.
Treatment options for small follicular center cell lymphoma depend on various factors such as the stage of the disease, the location and size of the lymph nodes, and the patient's overall health status. Options may include watchful waiting, radiation therapy, chemotherapy, targeted therapy, or a combination of these approaches. The ultimate goal of treatment is to control the disease and manage symptoms to improve the patient's quality of life.
