The Sex Related Y Gene, also known as SRY gene or sex determining region Y gene, is a critical gene found on the Y chromosome in humans and other mammals. It plays a fundamental role in determining the sex of an individual during embryonic development.
The SRY gene encodes a protein that acts as a transcription factor, which means it helps regulate the activity of other genes. Once activated, the protein produced by the SRY gene triggers a cascade of gene expression that guides the developing embryo towards male sexual differentiation. By initiating the formation of testes, the protein influences the production of male sex hormones, such as testosterone, which are responsible for the differentiation of male reproductive structures and secondary sexual characteristics.
In individuals with typical development, the presence of the SRY gene leads to the development of male reproductive organs. However, certain variations or mutations in this gene can result in disorders of sexual development (DSD) that affect the differentiation of the reproductive system, leading to atypical sexual development in individuals. For instance, individuals with certain mutations in SRY may exhibit ambiguous genitalia or other variations in sexual development.
Overall, the Sex Related Y Gene is a critical determinant of male sexual differentiation, orchestrating the process of sex determination during embryonic development in mammals.