SENESCENT CELL Meaning and
Definition
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Senescent cell refers to a type of cell in multicellular organisms that has undergone a significant loss of its replicative ability and is in a state of irreversible growth arrest. This phenomenon, known as senescence, is commonly associated with the aging process. Senescent cells arise due to various factors, including DNA damage, telomere attrition, cellular stress, and activation of specific signaling pathways.
Senescent cells exhibit distinct characteristics that differentiate them from normal, actively dividing cells. They display an enlarged and flattened morphology, known as a senescence-associated secretory phenotype (SASP), which is often accompanied by dysregulated gene expression patterns. Additionally, senescent cells exhibit increased levels of DNA damage, altered metabolism, and impaired cellular function.
The accumulation of senescent cells in tissues can have significant implications for overall organismal health. Senescent cells are known to secrete a range of factors that contribute to chronic inflammation, known as the senescence-associated secretory phenotype (SASP). These secreted factors can disrupt tissue homeostasis, promote the development of age-related diseases, and impair tissue regeneration and repair processes.
Understanding senescent cells and their role in aging and disease has led to the emergence of therapeutics targeting these cells, known as senolytics. Senolytic drugs aim to selectively eliminate senescent cells from tissues, with the potential to alleviate age-related conditions and promote healthier aging.
In summary, senescent cells are a type of non-dividing, aging cell that displays distinct characteristics and biological properties, contributing to the aging process and age-related diseases.
Common Misspellings for SENESCENT CELL
- aenescent cell
- zenescent cell
- xenescent cell
- denescent cell
- eenescent cell
- wenescent cell
- swnescent cell
- ssnescent cell
- sdnescent cell
- srnescent cell
- s4nescent cell
- s3nescent cell
- sebescent cell
- semescent cell
- sejescent cell
- sehescent cell
- senwscent cell
- sensscent cell
- sendscent cell
- senrscent cell
Etymology of SENESCENT CELL
The word "senescent" is derived from the Latin word "senescens", which is the present participle of "senescere". "Senescere" itself is derived from the Latin word "senex", meaning "old" or "old man". Therefore, the term "senescent cell" can be understood as a cell that has aged or become old.
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