SENDAI VIRUS FUSION PROTEIN Meaning and
Definition
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Sendai Virus Fusion Protein is a glycoprotein that plays a pivotal role in the life cycle of the Sendai virus, a member of the Paramyxoviridae family. This fusion protein is responsible for initiating the fusion process between the viral envelope and the host cell membrane, essential for viral entry into the target cell. It is synthesized as a precursor protein, commonly referred to as F0, and undergoes a series of post-translational modifications to become the mature, functional fusion protein.
The Sendai Virus Fusion Protein possesses several distinct functional domains. The receptor-binding domain facilitates attachment to the host cell surface receptors, a crucial step for viral entry. The fusion peptide domain promotes the merging of the viral and cellular membranes, facilitating the release of the viral genome into the host cell. Additionally, the heptad repeat regions, known as HR1 and HR2, play a critical role in the fusion process by mediating the conformational changes required for membrane fusion.
The fusion protein is highly immunogenic and can elicit host immune responses during viral infection. Its significance in viral pathogenesis is underscored by its ability to induce cell-cell fusion, leading to the formation of multinucleated syncytia, a characteristic cytopathic effect associated with Sendai virus infection.
Understanding the molecular structure and function of the Sendai Virus Fusion Protein has significant implications for the development of antiviral drugs and vaccines that target this essential protein, aiming to inhibit viral entry and replication. Studying the mechanism of action and interaction of this fusion protein provides insights into the fusion process that can potentially be exploited therapeutically to prevent or treat viral infections caused by Sendai virus and other related pathogens.
Common Misspellings for SENDAI VIRUS FUSION PROTEIN
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