The SENCAR Mouse is a term used to describe a specific strain or breed of laboratory mice commonly used in biomedical research. Developed at the University of Cincinnati, this strain is characterized by its heightened sensitivity to the carcinogenic effects of ultraviolet (UV) radiation.
The SENCAR Mouse derives its name from the acronym "SENsitive to CARcinogenesis," highlighting its unique susceptibility to develop skin tumors or cancers upon exposure to UV radiation or certain cancer-causing agents. This particular mouse strain has been instrumental in advancing our understanding of skin cancer development and evaluating potential preventive or therapeutic interventions.
These mice possess specific genetic alterations that make them highly responsive to environmental carcinogens, sensitizing them to the development of malignant skin tumors. As a result, they have become an invaluable tool in studying various aspects of skin carcinogenesis, including tumor initiation, promotion, and progression.
Researchers use the SENCAR Mouse to investigate the mechanisms underlying tumor formation, identify genetic factors influencing susceptibility to UV-induced skin cancer, and evaluate the efficacy and safety of different anti-cancer treatments. Additionally, these mice have been employed to test the potential toxic effects of new drugs or chemicals, aiding in the development of safe and effective therapeutic interventions.
Due to their unique characteristics and significance in skin cancer research, the SENCAR Mouse has become an essential model organism for studying the molecular pathways and genetic alterations involved in skin cancer development, providing valuable insights that contribute to the development of novel treatments and prevention strategies.
