Semicarbazide Sensitive Amine Oxidase (SSAO) is an enzyme that is found in various tissues and organs of the human body. It belongs to the family of copper-containing amine oxidases and is also known as vascular adhesion protein 1 (VAP-1) due to its role in leukocyte adhesion and migration.
SSAO plays a crucial role in the metabolism of amines, which are organic compounds containing a nitrogen atom. It catalyzes the oxidative deamination of primary amines, converting them into aldehydes, ammonia, and hydrogen peroxide. This process is important for the regulation of biogenic amines, such as histamine and serotonin, which are involved in various physiological functions.
Moreover, SSAO also participates in the generation of reactive oxygen species (ROS), which have implications in oxidative stress and inflammation. It has been implicated in various pathological conditions, including diabetes, atherosclerosis, and neurodegenerative disorders.
The sensitivity of this enzyme to the compound semicarbazide has been extensively studied, leading to its name "semicarbazide sensitive." This property has allowed the development of selective inhibitors targeting SSAO activity.
In summary, Semicarbazide Sensitive Amine Oxidase is an enzyme involved in the metabolism of amines and the generation of reactive oxygen species. It plays a role in various physiological functions and has been associated with several pathological conditions.
