SCHWARTZMANN REACTION Meaning and
Definition
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The Schwartzmann reaction is a biological response characterized by a local tissue reaction to bacterial endotoxins resulting in a secondary systemic inflammatory response. It was originally described by the Austrian scientist Joseph Schwartzmann in 1928. This reaction occurs when endotoxins, which are components of the outer cell wall of certain gram-negative bacteria, are injected into the body causing a cascade of reactions.
Upon introduction, the endotoxins trigger an immune response that leads to the release of various pro-inflammatory molecules, including cytokines, prostaglandins, and leukotrienes. This causes an initial localized inflammation in the tissue where the endotoxins entered the body, leading to redness, swelling, and pain.
If a sufficient amount of endotoxins enters the bloodstream, it can also induce a systemic inflammatory response, known as sepsis. This response can result in fever, low blood pressure, and multiple organ damage. If left untreated, sepsis can be life-threatening.
The Schwartzmann reaction is an important concept in the field of immunology and infectious diseases as it helps researchers and clinicians understand the pathogenesis of bacterial infections and sepsis. It also serves as a basis for studying the development of therapeutic interventions to prevent or mitigate the detrimental effects of endotoxin-induced inflammation.
Common Misspellings for SCHWARTZMANN REACTION
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Etymology of SCHWARTZMANN REACTION
The term "Schwartzmann reaction" refers to a physiological reaction characterized by a local inflammatory response followed by a systemic infection. It is named after Felix Schwartzmann, an Austrian physician who first described this reaction in 1928.
The etymology of the word "Schwartzmann" itself originates from the surname of Felix Schwartzmann. As a common convention in scientific nomenclature, eponyms are often used to honor the individuals who have made significant contributions to a particular field of study. In this case, the reaction was named after Felix Schwartzmann due to his pioneering work in identifying and describing this specific physiological response.
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