SCF RECEPTOR Meaning and
Definition
-
The SCF receptor, also known as stem cell factor receptor or c-Kit receptor, is a transmembrane protein involved in cell signaling and regulation of cellular processes. It is a type III receptor tyrosine kinase and is encoded by the c-Kit proto-oncogene.
The SCF receptor is predominantly expressed on the surface of hematopoietic stem cells, mast cells, and melanocytes, although its expression has also been identified in other tissues. It functions as a receptor for stem cell factor (SCF), also known as kit ligand or mast cell growth factor.
Upon binding to SCF, the receptor undergoes dimerization and autophosphorylation, leading to activation of downstream signaling pathways. Activation of the SCF receptor initiates several intracellular signaling cascades, including the PI3K-AKT, RAS-MAPK, and STAT pathways, which regulate diverse cellular processes such as cell growth, proliferation, survival, migration, and differentiation.
Mutations in the SCF receptor gene (KIT) are associated with various diseases and disorders. These mutations can lead to aberrant activation of the receptor and dysregulation of downstream signaling pathways, resulting in diseases such as gastrointestinal stromal tumors (GISTs), systemic mastocytosis, and acute myeloid leukemia.
In summary, the SCF receptor is a crucial protein involved in mediating the effects of stem cell factor and plays a vital role in regulating multiple cellular processes, particularly in hematopoietic cells and mast cells.
Common Misspellings for SCF RECEPTOR
- acf receptor
- zcf receptor
- xcf receptor
- dcf receptor
- wcf receptor
- sxf receptor
- svf receptor
- sff receptor
- sdf receptor
- scd receptor
- scc receptor
- scv receptor
- scg receptor
- sct receptor
- scr receptor
- scf eeceptor
- scf deceptor
- scf feceptor
- scf teceptor
- scf 5eceptor
Etymology of SCF RECEPTOR
The term "SCF receptor" is an abbreviation for Stem Cell Factor receptor. Stem Cell Factor (SCF) is a cytokine, also known as Kit ligand (KL), which plays a crucial role in the development and maintenance of blood cells, germ cells, and melanocytes. The receptor for SCF is called the SCF receptor or the Kit receptor.
The word "receptor" originated from the Latin word "receptus", which means "to receive". In the context of biology, a receptor refers to a protein molecule that recognizes and binds specific molecules, called ligands, initiating a specific cellular response.
Therefore, the term "SCF receptor" originated from the discovery of the respective receptor for the Stem Cell Factor (SCF) or Kit ligand, which is responsible for transmitting signals important for the regulation and function of stem cells and other cell types in the body.
Infographic
Add the infographic to your website:
