SAPROPTERIN DIHYDROCHLORIDE Meaning and
Definition
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Sapropterin dihydrochloride is a pharmaceutical drug classified as a synthetic form of the naturally occurring coenzyme tetrahydrobiopterin (BH4). It is also commonly known by its brand name, Kuvan.
Sapropterin dihydrochloride is primarily used to treat a group of genetic disorders called phenylketonuria (PKU). PKU is an inherited condition that impairs the ability to break down the amino acid phenylalanine, leading to a buildup of this compound in the body. Sapropterin dihydrochloride works by helping to restore the levels of BH4 in individuals with certain mutations in the genes responsible for the production of this coenzyme. BH4 is crucial for the conversion of phenylalanine into other important compounds, preventing the toxic accumulation of phenylalanine in PKU patients.
Administered orally in the form of tablets or a powder, sapropterin dihydrochloride is prescribed in combination with a phenylalanine-restricted diet to maintain phenylalanine levels within an acceptable range. Regular monitoring of blood phenylalanine levels is necessary to determine the appropriate dose of sapropterin dihydrochloride. This drug is not a cure for PKU, but it can help improve the management and long-term outcomes for individuals with this genetic disorder.
Common side effects of sapropterin dihydrochloride may include headache, diarrhea, nausea, and runny nose. Rarely, severe allergic reactions or elevated liver enzymes may occur. It is important for patients to consult with their healthcare provider before starting or altering the dosage of sapropterin dihydrochloride.
Etymology of SAPROPTERIN DIHYDROCHLORIDE
The word "sapropterin dihydrochloride" is a technical term used in the field of medicine. Let's break down the etymology of each component:
1. Sapropterin: The term "sapropterin" is derived from two parts - "sapro" and "pterin".
- "Sapro" is derived from the Greek word "sapros", meaning putrid or decayed.
- "Pterin" refers to a group of organic compounds that contain a pteridine ring structure.
2. Dihydrochloride: "Dihydrochloride" is composed of two parts - "di" and "hydrochloride".
- "Di" is a prefix meaning two or double.
- "Hydrochloride" refers to a salt form of a compound where the anion is accompanied by a chloride ion.
