RYANODINE RECEPTOR Meaning and
Definition
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The Ryanodine Receptor (RyR) refers to a class of calcium (Ca2+) release channels located in the membrane of intracellular organelles called sarcoplasmic reticulum (SR). It is named after the compound "ryanodine," which was initially isolated from a plant known as Ryania speciosa and found to have an affinity for this type of receptor. These receptor channels play a pivotal role in regulating calcium release from the SR into the cytoplasm during various physiological processes.
Ryanodine receptors can be found in various tissues, but are primarily known for their importance in skeletal muscle and cardiac muscle cells. In skeletal muscle cells, they are responsible for the release of calcium ions that trigger muscle contraction, enabling movement and locomotion. In cardiac muscle cells, they regulate the flow of calcium ions necessary for muscle contraction and relaxation to maintain proper heart function.
Generally, the RyR is opened by a process known as calcium-induced calcium release (CICR), wherein the influx of a small amount of extracellular calcium triggers the release of a larger amount of calcium from the SR. This mechanism ensures the synchronized and coordinated contraction of muscle fibers. Dysregulation or mutations in the RyR can lead to various pathologies, including skeletal muscle disorders and cardiac arrhythmias.
In summary, Ryanodine Receptors are calcium release channels found primarily in the sarcoplasmic reticulum membrane of muscle cells. They play a crucial role in the regulation of muscle contractions, including skeletal and cardiac muscle, by allowing the controlled release of calcium ions into the cytoplasm.
Common Misspellings for RYANODINE RECEPTOR
- eyanodine receptor
- dyanodine receptor
- fyanodine receptor
- tyanodine receptor
- 5yanodine receptor
- 4yanodine receptor
- rtanodine receptor
- rganodine receptor
- rhanodine receptor
- ruanodine receptor
- r7anodine receptor
- r6anodine receptor
- ryznodine receptor
- rysnodine receptor
- rywnodine receptor
- ryqnodine receptor
- ryabodine receptor
- ryamodine receptor
- ryajodine receptor
- ryahodine receptor
Etymology of RYANODINE RECEPTOR
The word "Ryanodine Receptor" is derived from the compound term "Ryanodine" and the word "Receptor".
The term "Ryanodine" originates from the name of the plant, Ryania speciosa. This plant belongs to the family Flacourtiaceae and is native to regions in South America. In 1948, the compound "ryanodine" was isolated from the roots and stems of Ryania speciosa by J.F. Green and C.G. Saunders.
The word "Receptor" is derived from the Latin term "receptus", which means "to receive". In biology and medicine, a receptor is a molecule or a molecular structure that is capable of binding to a specific substance in order to generate a physiological response.
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