ROFECOXIB Meaning and
Definition
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Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) belonging to the class of selective cyclooxygenase-2 (COX-2) inhibitors. It was previously marketed under the trade name Vioxx, but it is no longer available due to safety concerns.
As an NSAID, rofecoxib exerts analgesic, anti-inflammatory, and antipyretic effects by inhibiting the synthesis of prostaglandins. Prostaglandins are hormone-like substances that control various physiological functions, including inflammation, pain, and fever, by modulating the activity of COX enzymes. By selectively inhibiting COX-2, rofecoxib effectively reduces pain and inflammation without affecting the protective effects of COX-1 enzymes on the stomach lining.
Rofecoxib was primarily indicated for the treatment of osteoarthritis, rheumatoid arthritis, and acute pain conditions. However, it was withdrawn from the market in 2004 due to concerns regarding cardiovascular risks, particularly an increased incidence of heart attacks and strokes associated with long-term use of the drug.
The safety concerns surrounding rofecoxib highlighted the importance of thorough evaluation of the risks and benefits of any medication. The withdrawal of rofecoxib has resulted in stricter regulations regarding the approval and monitoring of COX-2 inhibitors and other NSAIDs. Patient safety remains a critical factor in the development and use of medications, and continuous research and monitoring are essential to ensure the effectiveness and minimize the possible adverse effects of these drugs.
Common Misspellings for ROFECOXIB
- eofecoxib
- dofecoxib
- fofecoxib
- tofecoxib
- 5ofecoxib
- 4ofecoxib
- rifecoxib
- rkfecoxib
- rlfecoxib
- rpfecoxib
- r0fecoxib
- r9fecoxib
- rodecoxib
- rocecoxib
- rovecoxib
- rogecoxib
- rotecoxib
- rorecoxib
- rofwcoxib
Etymology of ROFECOXIB
The word "rofecoxib" is a combination of two parts: "rofe" and "coxib".
The first part, "rofe", is believed to be derived from the chemical name for the molecule used as the active ingredient in the drug. However, the exact origin or meaning of this part is not clear.
The second part, "coxib", is a suffix used to classify a specific group of nonsteroidal anti-inflammatory drugs (NSAIDs). It is derived from the term "cyclooxygenase-2" (COX-2), which is an enzyme involved in the inflammatory process. COX-2 inhibitors, such as rofecoxib, selectively target and inhibit this enzyme.
Overall, "rofecoxib" is a constructed name that combines the unknown origin of "rofe" with the suffix "coxib", indicating its nature as a COX-2 inhibitor.
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