How Do You Spell RNASE H?

Pronunciation: [ˈɑː nˈe͡ɪs ˈe͡ɪt͡ʃ] (IPA)

The spelling of the word "RNase H" is determined by its pronunciation. The first syllable "R" is pronounced as /ɑr/ and followed by "Nase" pronounced as /neɪs/. The letter "H" is pronounced as /eɪtʃ/. RNase H is an endonuclease enzyme that degrades RNA strands in a DNA-RNA hybrid. The correct spelling is important in biochemical research, as spelling errors can lead to misinterpretation and confusion in experimental results.

RNASE H Meaning and Definition

1. RNase H is an enzyme that catalyzes the specific cleavage of the RNA strand in an RNA-DNA hybrid molecule. This enzyme is a member of the endonuclease family that recognizes and degrades RNA in an RNA-DNA duplex while leaving the DNA intact. The "RNase H" name is derived from its ability to hydrolyze or cleave the phosphodiester bonds of RNA.

   RNase H plays a crucial role in various cellular processes involving RNA-dependent DNA replication, DNA repair, and RNA processing. It is involved in the removal of RNA primers during DNA replication, promoting replication fidelity, and preventing the accumulation of RNA-DNA hybrids in the genome. Additionally, RNase H is essential for removing misincorporated ribonucleotides embedded in the newly synthesized DNA, thus maintaining genome stability.

   The enzyme predominantly functions in the nuclei of eukaryotic cells but is also present in the mitochondria. It exhibits high specificity for RNA-DNA hybrids, with preferential cleavage occurring at the RNA-DNA junction. Various structural and biochemical studies have revealed that RNase H adopts different mechanisms to recognize and hydrolyze the RNA component, forming unique interactions with the nucleic acids.

   Due to its significance in DNA replication and RNA processing, the study of RNase H has gained considerable importance in fields like molecular biology, genetics, and drug discovery. Inhibition or modulation of RNase H activity may have potential therapeutic applications, prominently targeting viruses that utilize RNA-dependent DNA synthesis, such as HIV.

Common Misspellings for RNASE H

• rnase h
• enase h
• dnase h
• fnase h
• tnase h
• 5nase h
• 4nase h
• rbase h
• rmase h
• rjase h
• rhase h
• rnzse h
• rnsse h
• rnwse h
• rnqse h
• rnaze h
• rnaxe h
• rnade h
• rnaee h
• rnawe h

Etymology of RNASE H

The acronym "RNase H" stands for Ribonuclease H. The term "ribonuclease" is derived from the combination of "ribo-", which refers to ribonucleic acid (RNA), and "-nuclease", which relates to an enzyme that cleaves nucleic acids. The "H" in "RNase H" refers to the class of ribonuclease H enzymes, designated H to differentiate them from other classes of ribonucleases.