REELER MICE Meaning and
Definition
-
Reeler mice refer to a specific strain of laboratory mice that possess a genetic mutation resulting in a neurological disorder known as reeler phenotype. These mice are widely used in scientific research to study the development and functioning of the central nervous system.
The name "reeler" derives from the characteristic abnormality seen in the mice's gait. Reeler mice exhibit an unsteady, staggering gait resembling the movement of a person who is reeling or stumbling, hence the term "reeler". This motor impairment is caused by the absence or dysfunction of a specific cell adhesion molecule called reelin, which is crucial for the normal migration and positioning of neurons during brain development.
In addition to the gait abnormalities, reeler mice display a range of phenotypic features associated with the improper formation of brain structures. These include a disorganized layering of neurons in the cortex, an enlarged cerebral ventricle, and an absence of cerebellar foliation. These structural abnormalities often result in functional deficits, such as impaired motor coordination, learning and memory impairments, and altered social behaviors.
The use of reeler mice in scientific research has provided valuable insights into various neurological conditions, including autism spectrum disorders, schizophrenia, epilepsy, and neurodegenerative diseases. By studying these mice, scientists can gain a better understanding of the underlying molecular and cellular mechanisms involved in brain development and how disruptions can lead to neurological disorders, ultimately paving the way for potential therapeutic interventions.
Common Misspellings for REELER MICE
- eeeler mice
- deeler mice
- feeler mice
- teeler mice
- 5eeler mice
- 4eeler mice
- rweler mice
- rseler mice
- rdeler mice
- rreler mice
- r4eler mice
- r3eler mice
- rewler mice
- resler mice
- redler mice
- rerler mice
- re4ler mice
- re3ler mice
- reeker mice
- reeper mice
Etymology of REELER MICE
The term "Reeler Mice" originates from the field of neuroscience and relates to a specific strain of laboratory mice known as "reeler mice".
The word "reeler" comes from the genetic mutation that leads to the neurological phenotype observed in these mice. Reeler mice have a mutation in a gene called "reelin" (officially known as RELN), which is responsible for producing the reelin protein. The reelin protein plays a crucial role in the development of the brain, particularly during embryonic and early postnatal stages.
Due to this mutation, reeler mice exhibit abnormal brain development, characterized by disorganized and inverted neuronal layers in the cerebral cortex and other brain regions. This results in a distinctive "reeling" or "reeling gait" behavior when the mice walk, giving them their name.
Infographic
Add the infographic to your website:
