RANBP Meaning and
Definition
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RANBP, acronym for "Ran-binding protein," refers to a class of proteins that play a crucial role in regulating nucleocytoplasmic transport. This group encompasses a diverse range of proteins found in various organisms, including humans. Ran-binding proteins interact with the small GTPase protein Ran and are involved in the transport of macromolecules, such as proteins and RNA, across the nuclear membrane.
RANBP is composed of several distinct domains that contribute to its functionality. These domains typically include a Ran-binding domain (RBD) and a zinc finger domain. The RBD enables the protein to interact with Ran while the zinc finger domain facilitates protein-protein interactions. Additionally, RANBP often contains domains that can bind to importins and exportins, other crucial factors in nuclear transport, further expanding its functional repertoire.
The interaction of RANBP with Ran-GTP is crucial for cargo trafficking between the cytoplasm and the nucleus. By binding to Ran-GTP, RANBP helps regulate the directionality and selectivity of nucleocytoplasmic transport. It acts as a cofactor in the dissociation of import cargoes from importins and promotes the recycling of exportins back to the nucleus. RANBP also assists in the assembly and disassembly of transport complexes and mediates the release of Ran-GTP from export complexes.
Overall, RANBP proteins are vital components of the cellular machinery responsible for precise and efficient nuclear transport. Their interactions with Ran and other transport proteins ensure that the correct molecules are transported to the appropriate cellular compartments.
Common Misspellings for RANBP
- eanbp
- danbp
- tanbp
- 5anbp
- 4anbp
- rznbp
- rsnbp
- rwnbp
- rqnbp
- rambp
- rajbp
- ranvp
- ranhp
- rangp
- ranbl
- ranb0
- eranbp
- reanbp
- dranbp
- rdanbp
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