How Do You Spell RADIATION LEUKEMIA VIRUSES?

Pronunciation: [ɹˌe͡ɪdɪˈe͡ɪʃən luːkˈiːmi͡ə vˈa͡ɪɹəsɪz] (IPA)

The term "Radiation Leukemia Viruses" refers to a group of retroviruses that have been associated with the development of leukemia following exposure to ionizing radiation. The pronunciation of this term can be broken down using the International Phonetic Alphabet (IPA) as /ˌreɪdiˈeɪʃən luˈkiːmiə ˈvaɪrəsəz/. Each segment of the word corresponds to a specific sound or combination of sounds in English, allowing for more accurate pronunciation and understanding of the term.

RADIATION LEUKEMIA VIRUSES Meaning and Definition

1. Radiation Leukemia Viruses (RadLV) refers to a group of retroviruses that can induce the development of leukemia or other hematopoietic malignancies in animals, particularly mice, when exposed to radiation. Retroviruses are a type of RNA virus that can integrate their genetic material into the host's DNA. RadLVs are classified as gammaretroviruses and belong to the Retroviridae family.

   Radiation Leukemia Viruses were first discovered in the mid-20th century during studies exploring the effects of ionizing radiation on leukemia development. It was observed that certain strains of mice exposed to X-ray radiation regularly developed leukemia. Further investigation revealed the presence of retroviruses in the leukemia cells, leading to the identification and characterization of the Radiation Leukemia Viruses.

   These viruses are known to induce leukemia by integrating their genetic material into the genome of hematopoietic cells, particularly stem cells, altering their cellular functions and promoting uncontrolled proliferation. The viruses can be transmitted vertically from infected mother mice to their offspring, and horizontally through proximity or direct contact.

   Radiation Leukemia Viruses have been extensively studied as model systems to understand the mechanisms underlying cancer development and the interplay between retroviruses and host cells. They have also provided valuable insights into the understanding of human leukemia and other hematopoietic malignancies. However, it is important to note that RadLVs are primarily studied in laboratory animals and their relevance to human diseases is still being explored.

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