PTEN Meaning and
Definition
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PTEN is an abbreviation for "Phosphatase and Tensin Homolog Deleted on Chromosome Ten," which refers to a protein-coding gene. It is a tumor suppressor gene and is known for its role in regulating cell growth and division. The PTEN gene is located on chromosome 10 in humans.
Functionally, PTEN acts as a dual-specificity protein phosphatase that controls several important cellular processes, including cell proliferation, migration, and apoptosis. It counteracts the activity of enzymes called protein kinases by removing phosphate groups from specific molecules, thereby reducing their function. By doing so, PTEN helps maintain proper cell signaling and prevents the uncontrolled cell growth and division that can lead to cancer.
Mutations or loss of the PTEN gene are frequently associated with various types of human cancers, particularly those of the breast, prostate, and brain. Abnormal PTEN function often disrupts the intricate balance of cell regulation, leading to uncontrolled cell growth and an increased risk of cancer development.
The abbreviation PTEN is commonly used to denote both the gene itself and the protein that it codes for. PTEN has garnered significant scientific interest and continues to be a target for research on cancer biology and potential therapeutic interventions. Additionally, PTEN analysis and testing are relevant in the clinical setting to assess cancer susceptibility and provide prognostic information.
Common Misspellings for PTEN
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