How Do You Spell PROTO ONCOGENE PROTEINS C ABL?

Pronunciation: [pɹˈə͡ʊtə͡ʊ ˈɒnkə͡ʊd͡ʒˌiːn pɹˈə͡ʊtiːnz sˈiː ˈabə͡l] (IPA)

The spelling of the word "Proto Oncogene Proteins c abl" can be understood through the use of the International Phonetic Alphabet. The first part of the word, "Proto Oncogene," is pronounced as [ˈproʊ.təʊ ˈɒŋ.kəʊ.dʒiːn], with the stress on the first syllable. The second part, "Proteins c abl," is pronounced as [ˈprəʊ.tiːnz siː eɪ biː el], with the stress on the second syllable of both "proteins" and "abl." This complex term refers to proteins involved in cell signaling and can play a role in cancer development.

PROTO ONCOGENE PROTEINS C ABL Meaning and Definition

1. Proto-oncogene proteins c-abl are a group of regulatory proteins that play a crucial role in cellular growth and proliferation. They are encoded by the c-abl gene, which is found in humans and other mammals. The c-abl gene is typically present in all cells and is responsible for producing a protein known as c-Abl tyrosine kinase.

   Proto-oncogene proteins c-Abl are multifunctional enzymes that are involved in various cellular processes, including cell division, DNA repair, and apoptosis (programmed cell death). They function as tyrosine kinases, meaning they can transfer phosphate groups to specific tyrosine residues on target proteins. This phosphorylation process regulates the activity and function of these target proteins.

   Under normal circumstances, proto-oncogene proteins c-Abl help regulate cell growth and division by promoting signals that prevent uncontrolled cell proliferation. However, certain genetic mutations or alterations can transform c-Abl into an oncogene, known as BCR-ABL fusion protein. This mutated protein has uncontrolled tyrosine kinase activity, leading to the abnormal growth and proliferation of cells, which can eventually give rise to cancer.

   The discovery of the c-Abl proto-oncogene and its role in cancer has provided valuable insights into the understanding and treatment of certain types of leukemia, such as chronic myeloid leukemia (CML). Inhibitors of the BCR-ABL fusion protein, known as tyrosine kinase inhibitors, have revolutionized the treatment of CML, helping to improve patient outcomes by specifically targeting the abnormal activity of proto-oncogene proteins c-Abl.

Common Misspellings for PROTO ONCOGENE PROTEINS C ABL

• oroto oncogene proteins c abl
• lroto oncogene proteins c abl
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• proro oncogene proteins c abl
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